A 16-year-old Indian-origin boy in the UK has claimed to have found a treatment for the most deadly form of breast cancer which is unresponsive to drugs.
Triple negative breast cancer does not have receptors and it can only be treated with a combination of surgery, radiation and chemotherapy which lowers the chance of survival.
“I’ve been basically trying to work out a way to change difficult-to-treat cancers into something that responds well to treatment. Most cancers have receptors on their surface which bind to drugs like Tamoxifen but triple negative don’t have receptors so the drugs don’t work,” Krtin was quoted as saying by The Sunday Telegraph.
“The prognosis for women with undifferentiated cancer isn’t very good so the goal is to turn the cancer back to a state where it can be treated. The ID4 protein actually stops undifferentiated stem cell cancers from differentiating so you have to block ID4 to allow the cancer to differentiate.
I have found a way to silence the genes that produce ID4 which turns cancer back into a less dangerous state,” Krtin added.
He has also discovered that upping the activity of a tumour suppressor gene called PTEN allows chemotherapy to work more effectively, so the dual treatment could prove far more effective than traditional drugs.
The therapy idea saw him shortlisted for the final of the UK-based young scientists programme titled The Big Bang Fair.
His efforts had hit the headlines last year when he won the Google Science Fair for creating a test which helps pick up the early signs of Alzheimer’s disease and potentially stop it spreading further.